|Gout and Hyperuricemia March 2017|
|Gout and Hyperuricemia. 2017; 4(1): 32-36
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Associated factors in patients with refractory gout
Jing Yang1, Jian-ling Dong1,*, Jinmei Zou1, Yu Zhang1, Lan Tian1, Min Li1
1Department of Rheumatology, Mianyang Central Hospital, 621000, Sichuan, China.
Department of Rheumatology, Mianyang Central Hospital, 621000, Sichuan, China.
Submitted on Feb. 16, 2017; accepted on Apr. 5, 2017.
©2017, Gout and Hyperuricemia. Published by Dong Fong Health Co. LTD in Taiwan. All right reserved.
Objective:To analyze associated factors of patients with refractory gout.
Methods:150 gout patients were recruited and divided into the refractory or nonrefractory gout group in this cross-sectional study. The association of refractory gout with variables was assessed using bivariate correlations. Subsequent binary logistic models with appropriate adjustments were used to find the associated factors of refractory gout patients.
Results:The prevalence of hypertension, gouty nephropathy and delayed prescription of urate-lowering therapy was higher in refractory gout group compared with controls (p<0.05). Patients with refractory had less awareness about gout and the goals of urate-lowering therapy, and poorer medication compliance (p<0.05). A multivariate unconditional logistic regression analysis showed five associated factors in patients with refractory gout, including disease duration (Odds ratio (OR)=1.31, p<0.001), gouty nephropathy (OR=4.64, p=0.024), awareness about goal of urate-lowering therapy (OR=0.20, p=0.005), delay in prescription of urate-lowering therapy (OR=2.97, p=0.034) and medication compliance (OR=4.74, p=0.003).
Conclusion:The study showed that gout patients with longer gout duration, gouty nephropathy, less knowledge about the goals of urate-lowering therapy, delayed use of urate-lowering therapy and poor drug compliance were more prone to develop refractory gout.
Key words:Gout; Refractory gout; Gouty nephropathy; Compliance