|Gout and Hyperuricemia March 2017|
|Gout and Hyperuricemia. 2017; 4(1): 5-11
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The relationships between components of gouty inflammation and cancers
1National University of Kaohsiung, Department of Kinesiology, Health and Leisure Studies, Kaohsiung, Taiwan.
Prof. Shun Jen Chang
National University of Kaohsiung, Department of Kinesiology, Health and Leisure Studies, Kaohsiung, Taiwan.
Submitted on May. 22 2017; accepted on May. 24, 2017.
©2017, Gout and Hyperuricemia. Published by Dong Fong Health Co. LTD in Taiwan. All right reserved.
Purpose:Gout is a chronic inflammatory disease, and gout patients are more likely to develop cancer; here, we review the relationship between the components of gouty inflammation and cancer.
Findings:Multiple steps are required to evoke gouty inflammation, including recognition and uptake of monosodium urate (MSU), ion exchange, inflammasome activation and release of interleukin (IL)-1β and IL-8. Most of the components related to gouty inflammation are associated with carcinogenesis, such as Toll-like receptor (TLR) 2, TLR4, ATP, connexins, pannexins, NLR family pyrin domain containing 3 (NLRP3) inflammasome, IL-1β and IL-8. Controversially, evidence also suggests that TLRs, connexins, NLRP3 inflammasome and IL-1β may be double-edged-swords in the influence of tumor progression.
Conclusion:Most of the components of gouty inflammation are related to carcinogenic, but some of the components exert promoting or inhibiting effects depending different tissues, stages and specific types of cancers.
Key words:Gout; Cancer; Inflammation; Carcinogenesis