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Gout and Hyperuricemia March 2017
Gout and Hyperuricemia. 2017; 4(1): 1-4
DOI: 10.3966/GH1703040101
Abstract  |  Full Text (HTML)  |  Full Text (PDF)
WD40-repeat proteins and gout
Chung-Jen Chen1, 2,*, Wei-Ting Liao3, Shun-Jen Chang4
1Kaohsiung Medical University Hospital, Department of Internal Medicine, Kaohsiung, Taiwan. 2Kaohsiung Medical University College of Medicine, Department of Internal Medicine, Kaohsiung, Taiwan. 3Kaohsiung Medical University College of Life Science, Department of Biotechnology, Kaohsiung, Taiwan. 4National University of Kaohsiung, Department of Kinesiology, Health and Leisure Studies, Kaohsiung, Taiwan.

*Corresponding author:
Dr. Chung-Jen Chen, MD
Kaohsiung Medical University Hospital, Department of Internal Medicine. No. 100, Tzyou 1st rd, Kaohsiung 807, Taiwan.
E-mail: 1030458@kmuh.org.tw
Tel: +886-7-3121101 ext 5029


Submitted on Mar. 6, 2017; accepted on Mar. 29, 2017.
©2017, Gout and Hyperuricemia. Published by Dong Fong Health Co. LTD in Taiwan. All right reserved.
Abstract
Purpose:Despite progress in understanding the genetics of hyperuricemia, many unanswered questions still remain about the genetic factors besides hyperuricemia that determine the development of gout. WD40-repeat (WDR) proteins are implicated in a variety of biologic functions including signal transduction, transcription regulation, apoptosis and etc. Whether this family is involved in the development of gout warrants further investigation.
Findings:Genetic variation in WDR1 was initially found to be associated with gout in the Han Chinese population in northern China. WDR77 is a novel androgen receptor cofactor that plays an important role in enhancing androgen receptor (AR) transcriptional activity in prostate cancer, which was prevalent in gout. Ubiquitin specific peptidase 12 (Usp12)/ Usp1-associated factor 1 (Uaf-1)/WDR20 complex plays a critical role in AR regulation. WDFY4 are associated with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), and could potentially be involved in gouty arthritis.
Conclusion:WDR proteins family consists of 277 proteins. What we know is very limited at present. In the future, studies about WDR proteins may provide a novel understanding for the mechanisms of gout.

Key words:Gout; WD40-repeat proteins; WDR